ProtoMap - A Map of Protein Space: An Interactive Web Site for Biological and Biomedical Investigations
This site classifies and groups all of the proteins in the Swiss-Prot and
TrEMBL databases. Transitivity is used to identify homologous proteins, and
within each group, every two members are either directly or transitively
related. Transitivity is applied restrictively in order to prevent
unrelated proteins from clustering together. The classification is done at
different levels of confidence, and results in a hierarchical organization
of all the proteins.
The resulting classification splits the protein space into well-defined
groups of proteins, most of them closely correlated with natural biological
families and superfamilies. The hierarchical organization may help to
detect finer subfamilies that make up known families of proteins, as well
as interesting relations between protein families.
